eClinical Research Peer-Reviewed Insights for Clinical Excellence

eClinical Research

Peer-Reviewed Insights for Clinical Excellence

Latest Articles

Beyond the Randomized Trial: How Real-World Evidence Is Redefining Clinical Practice in 2024
Clinical Innovation

Beyond the Randomized Trial: How Real-World Evidence Is Redefining Clinical Practice in 2024

Real-world evidence derived from electronic health records, claims databases, and patient registries is increasingly informing clinical decision-making and regulatory policy across US healthcare institutions. As the FDA and CMS accelerate frameworks for integrating observational data alongside traditional trial findings, precision medicine and population health strategies stand to be fundamentally transformed.

Shaky Foundations: Confronting the Replication Failures Threatening the Integrity of US Clinical Research
Research Methodology

Shaky Foundations: Confronting the Replication Failures Threatening the Integrity of US Clinical Research

A growing body of evidence suggests that a substantial proportion of peer-reviewed clinical trial findings cannot be reliably reproduced, exposing systemic vulnerabilities in study design, reporting practices, and institutional incentives. This analysis examines the structural causes of the reproducibility crisis and outlines evidence-based strategies for strengthening the scientific foundation of clinical medicine in the United States.